〔Abstract〕 Objective To explore the effects of Dagliejing on insulin resistance, blood lipid level and homocysteine (Hcy) intype 2 diabetes mellitus. Methods 200 patients with type 2 diabetes from January 2020 to June 2021 in Xinhui District Second People's Hospital of Jiangmen were selected and divided into observation group and control group according to random number table, 100 cases in each group. The control group was treated with conventional drugs and the observation group was treated with Dagliejing. The insulin resistance, blood lipid level and Hcy level of the two groups were compared. Results the islets of the two groups before treatment β Cell function index (HOMA – β). There was no significant difference in insulin resistance index (HOMA-IR) (P > 0.05) β HOMA – IR increased in varying degrees, HOMA – IR decreased in varying degrees, and HOMA – β Compared with the control group, HOMA-IR was lower than the control group, the difference was statistically significant (P < 0.05); there was no significant difference in high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) between the two groups before treatment (P > 0.05) After treatment, HDL-C of the two groups increased in varying degrees, LDL-C and TC decreased in varying degrees, and HDL-C of the observation group was higher than that of the control group, LDL-C and TC were lower than that of the control group, the difference was statistically significant (P < 0.05); there was no significant difference in homocysteine amino acid (Hcy) between the two groups before treatment (P > 0.05) After treatment, the Hcy of the two groups decreased to varying degrees, and the observation group was lower than that of the control group (P < 0.05). Conclusion the application of Dagliejing in the treatment of type 2 diabetes can improve the insulin resistance, blood lipid level and Hcy level.