〔Abstract〕 Objective To investigate the correlation between the degree of liver cirrhosis and the pathological changes of gastric mucosa in patients with hepatitis B. Methods The clinical data of 92 patients with hepatitis B Cirrhosis admitted to the First Affiliated Hospital of Henan University of Science and technology from January 2019 to January 2020 were retrospectively analyzed, according to the degree of illness, the patients were divided into mild group (42 cases) , moderate group (30 cases) and severe group (20 cases) , the indexes of Serum Liver Fibrosis, Gastric Mucosa inflammation and the degree of gastric mucosa lesion were compared in four groups, and the relationship between them and the degree of hepatitis B Cirrhosis was analyzed. Results The levels of Laminin (LN) , hyaluronic acid (HA) , Procollagen type III (PC III) and Collagen type IV (IV c) in mild, moderate and severe groups were higher than those in healthy groups, the degree of gastric mucosal lesion was higher than that of healthy group, and the above indexes were higher in severe group than in moderate group than in mild group than in healthy group (P < 0.05) , the degree of liver cirrhosis was positively correlated with the pathological changes of gastric mucosa (r = 0.539, P < 0.01). Conclusion The patients with hepatitis B and liver cirrhosis are easy to be complicated with inflammatory lesions of gastric Mucosa, and the degree of lesions is closely related to the degree of liver cirrhosis.