〔Abstract〕 Objective To study the clinical value of combined treatment of cefoperazone sodium and sulbactam sodium for injection and moxifloxacin hydrochloride in the treatment of patients with severe pneumonia. Methods A total of 79 patients with severe pneumonia admitted to Fujian Provincial Geriatric Hospital from May 2019 to August 2020 were included in this study, and they were divided into a control group (42 cases, cefoperazone sodium and sulbactam for injection) according to the "computer randomization method" Conventional sodium treatment) and observation group (37 cases, cefoperazone sodium and sulbactam sodium for injection combined with moxifloxacin hydrochloride); observe the clinical efficacy, antipyretic time, inflammatory factors before and after treatment, and the improvement of quality of life. Results The total effective rate of treatment in the observation group was as high as 97.2%, while that in the control group was only 83.3%. The difference between the groups was statistically significant (P < 0.05). After treatment, the observation group of patients with antimicrobial treatment, mechanical ventilation, antipyretic time and the disappearance of sputum and lung rales were all shorter than those in the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of interleukin (IL)-2, IL-4 and C-reactive protein (CRP) in the observation group were lower than those in the control group, and the difference was statistically significant (P < 0.05). After treatment, the quality of life scores of patients in the observation group, such as physiological function, emotional function, and social function, were higher than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion To implement drug treatment for patients with severe pneumonia, it is recommended to use the combined treatment of cefoperazone sodium and sulbactam sodium for injection and moxifloxacin hydrochloride, which can shorten the antipyretic time, improve the clinical efficacy and improve the quality of life of the patients.