〔Abstract〕 Objective To investigate the risk factors of myocardial damage in children with rotavirus enteritis (RVE). Methods The clinical data of 82 children with RVE admitted to the New District Hospital of the First Affiliated Hospital of Henan University of Science and technology from March 2018 to April 2019 were analyzed retrospectively, to analyze the influencing factors of myocardial damage in children with RVE. Results The incidence of myocardial damage was 35.37% in 29 of 82 children with RVE, and the incidence of dehydration and acidosis in the group with RVE was significantly higher than that in the group without RVE (P < 0.05) , age, acidosis and dehydration are risk factors for myocardial damage in children with RVE. The younger the age, the greater the risk of myocardial damage. Conclusion Age, dehydration and acidosis are the risk factors of myocardial damage in children with RVE. The younger the age, the greater the risk of myocardial damage.