〔Abstract〕 Objective To observe the efficacy of acupuncture combined with Huoxue Qu Feng external washing prescription in the treatment of patients with type 2 diabetes mellitus and chronic eczema with blood stasis and wind dryness syndrome. Methods 70 patients with type 2 diabetes mellitus and chronic eczema with blood stasis and wind dryness syndrome were selected from January 2019 to December 2020 in Guangzhou Xinhai Hospital. They were divided into control group and observation group by random number table, with 35 cases in each group. All the patients were given basal treatment such as hypoglycemia, and the control group was treated with oral Ebastine Tablets combined with Mometasone Furoate Cream, while observation group was treated with acupuncture combined with Huoxue Qufeng external washing formula. The eczema area and severity index (EASI), pruritus VAS score, fasting blood glucose (FPG) and 2-hour postprandial blood glucose (2hPG) were observed before and after treatment; adverse drug reactions were recorded. Results After treatment, the EASI score of the two groups were lower than that before treatment (P < 0.05) and there was no significant difference between the two groups (P > 0.05). After treatment, the pruritus VAS of the two groups were lower than that before treatment (P < 0.05）, and pruritus VAS of observation group was lower than that of the control group (P < 0.05). Two groups had no significant difference in FPG and 2hPG before and after treatment (P > 0.05). The total effective rate of the observation group was 80.00%, while that of control group was 85.71%, the difference was not statistically significant (P > 0.05). The incidence of side effect in the observation group was 0.00%, while that in control group was 17.14%, the difference was statistically significant (P < 0.05). Conclusion Acupuncture combined with Huoxue Qu Feng external washing prescription is effective in treating type 2 diabetes mellitus and chronic eczema with blood stasis and wind dryness syndrome, with low side effects.