〔Abstract〕 Objective To analyze BRCA gene mutation in patients with epithelial ovarian cancer (EOC) and its relationship with clinical data. Methods The newly treated EOC patients in the Department of Gynecology of Shenzhen Second People's Hospital from November 2015 to September 2017 were collected and tested for BRCA gene mutation status. According to the BRCA genetic test Results, the patients were divided into the BRCA gene mutation positive group and the negative group. And statistical analysis of patient clinical data was performed. Results A total of 21 patients with EOC without family history of disease were enrolled, including 3 cases of BRCA gene mutation(the mutation rate of BRCA gene was 14.3 %), all of which were BRCA1 gene mutations. There were no statistically significant differences in serum CA-125, HE4, FIGO stage, pathological types, degree of tissue differentiation and sensitivity to platinum drugs between two groups. The tumor-free survival of the positive group was longer than that of the negative group, but the overall survival was shorter in the positive group than that in the negative group, and the difference was not statistically significant. Conclusions The mutation rate of BRCA gene in EOC patients is lower than domestic reports, but it remains at the level reported in multiple countries around the world. There was no correlation between BRCA gene mutation and clinical data.