〔Abstract〕 Objective To investigate the effects of lower cholesterol treatment on cerebral artery elasticity in patients with ischemic stroke (CIS). Methods From January 2020 to December 2020, 80 patients with CIS in Guiji Hospital were selected as research objects, randomly divided into observation group and control group, and 40 cases, the control group gave routine intervention, observation group On the basis of the control group, a strengthening of the cholesterol treatment was administered, and the blood lipid changes before and after the treatment before and after treatment were observed after 3 months, and the relevant parameters were checked and the parameters were recorded and compared to the parameters. Results The total cholesterol (TC), triamylglycerol (TG), low density lipoprotein cholesterol (LDL-C), pulsation index (PI), and resistance index (RI), and the resistance index (RI), and the pulsation index (PI), and the resistance index (RI). The observation group was significantly lower than the control group, and the difference was statistically significant (P < 0.05); high-density lipoprotein cholesterol (HDL-C) in two groups after treatment, the peak flow rate (Vs) of the shrinkage period (Vd), the peak flow rate of diastolic The shrink/diastolic flow rate ratio (S/D) is higher than the treatment, and the observation group is higher than the control group, and the difference has statistically significant (P < 0.05). Conclusion Treatment of lower cholesterol treatment for CIS patients can effectively improve the blood lipid level and cerebral arterial elasticity of patients.