〔Abstract〕 Objective To explore the correlation between blood parameters and infarct size in patients with acute cerebral infarction (ACI). Methods 96 patients with ACI who were diagnosed and admitted in the Southeast Central Hospital of Dongguan from January 2019 to December 2019 were chosen as the observation group, and 96 healthy subjects during the same period were chosen as the control group, and the blood parameters levels of Neutrophil to Lymphocyte Ratio (NLR), Red blood cell Distribution Width (RDW), Platelets (PLT), Platelet Distribution Width (PDW), Mean Platelet Volume (MPV), Total Cholesterol (TC), Low-Density Lipoprotein Cholesterol (LDL-C) ) and Homocysteine (Hcy) were measured , and the correlation of NLR、RDW、 Hcy and infarct size through analysis of Spearman. Results Compared with the control group, the NLR, RDW, MPV and Hcy of the cerebral infarction group were significantly increased, and the PLT was significantly reduced, and the differences were statistically significant (P < 0.05).There was no statistical significance (P > 0.05) between the PLT levels and infarct size. The levels of MPV in the large area infarction is higher than the group of the small area infarction and medium area infarction,and the difference wasstatistically significant (P < 0.05). The levels of NLR, RDW and Hcy are significantly increased in ACI patients,which are related to the area of cerebral infraction(P < 0.05) . The Spearman correlation analysis showed that the levels of NLR, RDW, and Hcy were closely positive correlated with area of cerebral infraction. Conclusion The combined detection of NLR, RDW and Hcy has good clinical value for the infarction area of ACI .