〔Abstract〕 Objective To evaluate the impacts of electronic mobile devices on postoperative therapeutic effect and quality of life of patients with acute myocardial infarction (AMI). Methods The total of 96 AMI patients who received the primary percutaneous coronary intervention (PCI) in our hospital (March 2017 to February 2019) were randomly divided into control group and observation group with 48 cases in each group. The conventional nursing care and cardiac rehabilitation care with the utilization of electronic mobile devices were implemented to two groups of patients, respectively. The left ventricular ejection fraction (LVEF), quality of life, the time and cost during hospitalization, as well as satisfaction rate of patients were compared between two groups. Results The basal LVEF and quality of life of patients were not significantly different between the two groups (P > 0.05), both of which were significantly improved after nursing care. Of note, the LVEF and quality of life of patients who received cardiac rehabilitation care with the utilization of electronic mobile devices were significantly higher than that of control patients (P < 0.05). Moreover, the patients in the observation group had less time and cost during hospitalization than that of control patients (P < 0.05). Meanwhile, the satisfaction rate of patients was significantly increased by cardiac rehabilitation care (95.83% vs 79.17% for observation group vs. control group, P < 0.05). Conclusions Cardiac rehabilitation care with the utilization of electronic mobile devices substantially improves cardiac function, quality of life, and satisfaction rate but reduces the economic burden of AMI patients after PCI surgery.