〔Abstract〕 Objective To investigate the infl uencing factors of abnormal calcium and phosphorus metabolism in patients with end-stage renal failure on maintenance hemodialysis. Methods A retrospective selection of 100 patients with end-stage renal failure who underwent maintenance hemodialysis in Huidong Hospital Affi liated to Guangdong Medical University from January 2019 to March 2020, according to the patients' serum calcium, serum phosphorus and parathyroid hormone ( The level of PTH was divided into the standard group and the non-standard group. The general related data and laboratory-related indicators of the two groups of patients were compared, and the risk factors affecting the abnormal calcium and phosphorus metabolism of the patients were analyzed by Logistic regression. Results Among 100 patients, 52 were in the up-to-standard group and 48 were in the under-standard group. The proportion of patients in the under-standard group was ≥70 years old, BMI≥24 kg·m-2, and dialysis time ≥ 2 years. In the standard group, the Scr level was higher than the standard group, and the Hb and GFR levels were lower than the standard group. Multivariate logistic regression analysis showed that age ≥ 70 years old, BMI ≥ 24 kg·m-2, dialysis time ≥ 2 years, and GFR < 2.03 mL·min-1 were independent risk factors for calcium and phosphorus metabolism in patients. Conclusion Age≥70 years, BMI≥24 kg·m-2, dialysis time≥2 years, GFR < 2.03 mL·min-1 are independent risk factors for calcium and phosphorus metabolism in patients with end-stage renal failure on maintenance hemodialysis. The above should be paid attention to when clinically treating patients.