〔Abstract〕 Objective To explore the application of general anesthesia combined with thoracic paravertebral nerve block in infant thoracoscopic surgery. Methods A total of 60 infants and young children undergoing thoracoscopic lobectomy for pulmonary cystadenoma or isolated lung who were admitted to the Guangdong Provincial Maternity and Child Health Hospital from July 2018 to January 2021 were selected and randomly divided into groups C (n = 30) and N Group (n = 30). Group C underwent general anesthesia routinely, and group N underwent paravertebral nerve block after induction of anesthesia. The intraoperative sufentanil dosage, resuscitation time, heart rate (HR) and mean blood pressure (MAP) at 30 min (T1) and 60 min (T2) after tracheal intubation were recorded respectively, and 2h after tracheal tube removal (T3) And 6h (T4) children's HR, MAP, and pain scores. Result The dosage of sufentanil in group N was signifi cantly less than that in group C, and the recovery time was shorter than that in group C. The difference was statistically signifi cant (P < 0.05); there was no statistical comparison of HR and MAP between the two groups at T1 and T2 time points The HR and pain scores of children in group N were signifi cantly lower than those in group C at T3 and T4, the difference was statistically signifi cant (P < 0.05), and the difference in MAP comparison was not statistically significant (P > 0.05). Conclusion General anesthesia combined with paravertebral nerve block can significantly reduce the amount of sufentanil during surgery, promote the recovery of children, and reduce the postoperative pain of infants and young children undergoing thoracoscopic surgery.