〔Abstract〕 Objective Study on the effect of Fuling Sini Decoction on immune regulation of patients with septiccardiomyopathy from the perspective of Th17/Treg immune imbalance. Method 56 patients with septic cardiomyopathy were randomly divided into treatment group and control group 28 cases respectively. The control group was treated with routine treatment. The treatment group was given poring Sini Decoction orally on the basis of the control group for 7 days. The acute physiological and chronic health status scores (apache- Ⅱ), systemic infection related organ failure score(sofa), TCM syndrome score were compared in the two groups before and after treatment. The IL-6, IL-10, cTnI, NT-proBNP, CD4+ /CD8+ , Th17/Treg were compared in the two groups before and after treatment. The ICU stay time and mortality rate at 28d were statistically analyzed. Results Seven days after treatment, the TCM symptom score, Apache- Ⅱ score and SOFA score of the two groups were signifi cantly lower than those before treatment, and the improvement of the treatment group was significantly better than that of the control group (P < 0.05); IL-10 and CD4+ /CD8+ of the treatment group were signifi cantly higher than those of the control group, while IL-6 and Th17/Treg of the treatment group were signifi cantly lower than those of the control group, and the differences were statistically signifi cant (P < 0.05). Before treatment, the cTnI and NT-proBNP levels of the two groups of patients were not statistically different (P> 0.05); after treatment, the cTnI and NT-proBNP levels of the two groups of patients decreased to varying degrees, and the observation group was lower than the control group. The difference was statistically signifi cant (P < 0.05).The 28-day case fatality rate of the observation group was 5 cases (17.86%), compared with 6 cases (21.43%) in the control group, the difference was not statistically signifi cant (P > 0.05).The length of ICU stay in the observation group was (6.84 ± 1.53) days, which was shorter than (8.25 ± 1.69) days in the control group, and the difference was statistically signifi cant (P < 0.05). Conclusion Fuling Sini Decoction can improve immune imbalance, inhibit infl ammatory reaction, protect myocardium and improve short-term prognosis of patients with septic cardiomyopathy through immune regulation.