〔Abstract〕 Objective To observe the effi cacy of Yupingfeng granule in preventing and treating acute exacerbation of chronic obstructive pulmonary disease and improving lung function and the safety of long-term use. Method A total of 60 patients with stable chronic obstructive pulmonary disease admitted to Heyuan Hospital of Chinese Medicine from June 2017 to June 2019 were randomly divided into two groups, with 30 cases in each group. Patients in the control group were treated with conventional methods, and the observation group was treated with Yupingfeng granules on the basis of the treatment of the control group. All cases were followed up for 12 months. The number and duration of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and the improvement of lung function during the follow-up period of the two groups were observed. Results The number and duration of AECOPD in the observation group were less than those in the control group, and the difference was statistically signifi cant (P < 0.05); Before treatment, there was no signifi cant difference in lung function between the two groups of patients (P > 0.05); After treatment, the pulmonary function of the observation group was better than that of the control group, and the difference was statistically signifi cant (P < 0.05); no adverse reactions were observed in all cases during the medication. Conclusion Treatment of chronic obstructive pulmonary disease with Yupingfeng granule has a signifi cant stabilizing effect, which can effectively promote the patient's rehabilitation during the stable period of disease, improve lung function, delay the acute attack and development of slow-blockinglung, and improve the patient's quality of life.