〔Abstract〕 Objective To investigate the relationship between the mRNA expression of peroxisome proliferator activated receptor gamma (PPARG)、cell death inducing DFFA like effector a (CIDEA)、enoyl-CoA hydratase domain containing 3 (ECHDC3)and cingulin (CGN) in peripheral blood and the level of blood lipid in obese patients with Type 2 diabetes mellitus (T2DM). Methods From April 2020 to January 2021, 23 newly diagnosed T2DM patients with obesity (T2DM+OB) in the outpatient and inpatient treatment of Xinjiang Production and Construction Corps Hospital were selected, and 43 healthy people (NC) with normal body mass index (BMI) in the physical examination center were selected. 48 cases of simple obesity (OB) were the research objects. Collect the general data of the research subjects, use the automatic biochemical analyzer to determine the blood lipid level, and detect the mRNA expression of peripheral blood PPARG, CIDEA, ECHDC3 and CGN by real-time fl uorescent quantitative polymerase chain reaction (qRT-PCR) Level. Results The age and TG level in T2DM+OB group were higher than those in NC group and OB group (P < 0.05). The body weight, BMI and LDL–C level in T2DM+OB group and OB group were higher than those in NC group (P < 0.05). The mRNA expression levels of PPARG and CIDEA in peripheral blood in T2DM+OB group were signifi cantly lower than those in NC and OB groups (P < 0.05). There was no signifi cant difference in the mRNA expression levels of ECHDC3 and CGN in peripheral blood among all groups. The mRNA levels of PPARG and CIDEA in peripheral blood were signifi cantly negatively correlated with TC and TG (P < 0.05). The mRNA levels of ECHDC3 and CGN in peripheral blood were not signifi cantly correlated with the level of blood lipid. Conclusion The increased mRNA expression of PPARG and CIDEA in peripheral blood may slow down the occurrence of T2DM in obese people by regulating plasma TC and TG levels. The mRNA expression of PPARG and CIDEA in peripheral blood is expected to be a potential biomarker for risk prediction and prognosis evaluation of T2DM in obese people.