〔Abstract〕 With the advancement of endoscopic techniques and anesthesia techniques, painless gastrointestinal endoscopy is widely used, and more and more gastrointestinal diseases can be passed through painless gastrointestinal endoscopy as an important indicator for clinicians to diagnose diseases. As elderly patients become aging, the body's compensatory ability decreases, painless gastrointestinal endoscopy reduces the pain of elderly patients and increases comfort. A brief review of the main points of painless gastrointestinal endoscopy in elderly patients is provided to provide guidance for better care of elderly patients.