〔Abstract〕 Objective To explore the clinical efficacy of combined Chinese and Western medicine in the treatment of mycoplasma infection in urogenital tract and the recurrence situation within two years after the end of the course of treatment. Methods 248 patients were divided into the treatment group (124 patients) and the control group (124 patients). The treatment group was received sensitive antibiotic and traditional Chinese medicine based on differentiation of symptoms and signs. The control group was only received sensitive antibiotic every day for two weeks. And then recheck the recurrence after the course of treatment two years later. Results The cure rate of the observation group was 90.3% higher than that of the control group 72.6%, the difference was statistically signifi cant (P < 0.01). During the treatment and observation of the two groups of patients, no obvious adverse reactions occurred; after treatment, the negative rate of UU infection in observation group was 92.5% higher than 73.7% in control group. The negative rate of simple Mycoplasma hominis (MH) infection in the observation group was 87.5% higher than that in the control group was 68.8%. The negative rate of MH+UU mixed infection in the observation group was 83.3.0% higher than that of the control group 75.0%, and the difference was statistically signifi cant (P <0.01). The two-year recurrence rate of the observation group was 6.5% lower than that of the control group 22.6%, and the difference was statistically signifi cant (P < 0.05). Conclusion Combined treatment by traditional Chinese and Western medicine for mycoplasma infected in genitourinary tract was better than single Western medicine.