〔Abstract〕 Objective To explore the modifi able risk factors and protective factors associated with breast cancer in Chinese women. Methods Case-control studies about factors associated with breast cancer in Chinese women were searched in databases at home and abroad, published from 2009 to 2019. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, Meta-analysis was performed using Stata 12.0 software. Results 25 studies involving 10054 breast cancer patients and 12620 controls were fi nally included. The Meta, analysis showed that the age of menarche ≥ 14 years 〔0.55(0.27,1.11)〕, menopause〔0.99(0.69,1.42)〕and childbearing〔0.96(0.68,1.37)〕 were not associated with breast cancer, but family history of breast cancer〔3.44(2.23,5.31)〕, family history of cancer〔2.27(1.67,3.10)〕, benign breast disease〔4.00(2.702,5.93)〕,irregular menstruation〔1.96(1.56,2.44)〕，abortion〔2.018(1.412,2.885)〕, no breastfeeding〔1.39(1.27,1.54)〕, oral contraceptive (OC) 〔1.575(1.11,2.234)〕, smoking〔2.2(1.71,2.83)〕, passive smoking〔1.537(1.22,1.936)〕, alcohol intake〔1.57(1.28,1.92)〕, lack of physical activity〔1.49(1.35,1.64)〕, overweight（BMI ≥ 24）〔1.264(1.07,1.494)〕 and obesity（BMI ≥ 28）〔1.79(1.344,2.383)〕 were high risk factors for breast cancer. Among them, smoking, drinking, overweight and obesity, oral contraceptives, breastfeeding and physical exercise are controllable risk factors for breast cancer in women. Conclusion In order to reduce the risk of breast cancer in Chinese women, effective measures should be taken to change the population exposure to controllable factors, such as strengthening physical exercise, controlling smoking and drinking, avoiding oral contraceptives, and controlling weight.