〔Abstract〕 Objective To measure the intima-media thickness ( IMT) of carotid artery by ultrasound in patients with acquired immunodefi ciency syndrome (AIDS) without intervention , and to explore the relationship between IMT and blood lipid metabolism. Methods Thirty-fi ve AIDS patients without any antiviral therapy treated in the Fifth affi liated Hospital of Zunyi Medical University (Zhuhai) from June 2018 to January 2020 were selected as the observation group, and 40 cases of normal physical examination in the same period were selected as the control group. Observing the correlation between IMT and blood lipids levels in each group, and comparing the differences of IMT and blood lipids levels between the two groups. Results IMT was positively correlated with total cholesterol (TC) and triglyceride (TG) levels in both the observation group and the control group ,and high density lipoprotein cholesterol (HDL-C)was negative correlated with IMT in the observation group. The values of IMT, TC and TG in the observation group were higher than those in the control group, while HDL-C was lower than that in the control group.The difference was statisticall significant. Conclusion IMT and blood lipids have changed in varying degrees in patients with AIDS before intervention, and there is a correlation between them. The effects of early HIV infection on blood lipids and IMT are considered.