〔Abstract〕 Objective To analyze the full human papilloma virus (HPV)-DNA typing and quantitative detection results of high-risk self-examination population of condyloma acuminata. Methods From October 2017 to October 2019, 1980 patients with condyloma acuminatum and asymptomatic high-risk self-examination individuals who were subjected to HPV-DNA typing and quantitative detection at Foshan traditional Chinese medicine hospital were enrolled in the study. Flow fl uorescence hybridization was used for full typing and quantitative detection of HPV-DNA, and the results were analyzed. Results The positive detection rate of HPV-DNA in females was 53.48%, higher than 39.45% in males (P < 0.05). The positive detection rates of 6/11, 16, 16+16/11, 18, 18+6/11 type were 24.19%, 6.01%, 3.94%, 3.38%, and 3.33%. The HPV-DNA test results of different populations showed that the order of the positive detection rate of HPV-DNA from high to low was as follows: people with condyloma acuminatum (74.02%), people with history of condyloma acuminatum (47.34%), people whose sexual partners or spouses had condyloma acuminatum (43.43%), high-risk sexual history self-examination population (32.49%), and people with other sexually transmitted diseases (21.38%). In HPV-DNA positive patients, those with anxiety and depression accounted for 69.12% and 55.65%, respectively. Conclusion The positive rate of HPV-DNA is higher in females with condyloma acuminatum and asymptomatic high-risk self-examination population than in males. Besides, 6/11 infection is more common. All patients have anxiety and depression. For asymptomatic high-risk population, knowledge of sexually transmitted diseases should be strengthened, psychological intervention should be carried out, and HPV-DNA testing should be improved, thus promoting early treatment of patients.