〔Abstract〕 Objective To explore the value of CRRT in the treatment of severe trauma. Methods A retrospective study of 48 patients with severe trauma and acute kidney injury in the Department of Critical Care Medicine of the 909th Hospital of the Joint Logistics Force from January 2010 to November 2016. 26 patients who underwent early CRRT were the observation group. They were treated with conventional symptomatic treatment and performed as indicated. 22 cases treated with CRRT served as the control group. Results The use rate of vasoactive drugs, the incidence of ARDS, and the CRRT time in the observation group were lower than those in the control group (P < 0.05). The 24-hour LCR of the observation group was higher than that in the control group (P < 0.05). Conclusion Early CRRT for patients with severe trauma can correct blood coagulation function as soon as possible and shorten the course of CRRT and the length of hospital stay.