〔Abstract〕 Objective Optimized the sequence of the cervical cranial combined high-resolution vascular wall MR examination imaging to obtain the best spatial resolution, sharpness of vascular vessel wall and scanning time. Methods Retrospectively analyzed the images of 128 patients who underwent high-resolution vascular wall MR examination of the cervical and cranial at Shenzhen Second People's Hospital from August 14, 2018 to March 9, 2020, to evaluate the image quality of the two high-resolution sequences of the cervical coronal and cranial sagittal and the cervical cranial combined high-resolution vascular wall MR examination imaging. Results The comprehensive scores of the clarity of plaque display, the sharpness of vascular wall, the number and clarity of cerebral microvascular display of the cervical cranial combined high-resolution vascular wall MR examination imaging were signifi cantly better than that of cervical coronal and cranial sagittal examination imaging,The difference was statistically signifi cant (P < 0.05). Compared with the two high-resolution sequences scans of the cervical coronal and the cranial sagittal , the scanning time of the cervical cranial combined high-resolution vascular wall MR scan was signifi cantly shorter and the spatial resolution was better. Conclusion The cervica cranial combined high-resolution vascular wall MR scanning can be used as a routine examination sequence for high-resolution scanning of cervical and cranial vascular walls, but color Doppler ultrasound is required to exclude carotid and vertebral artery plaque lesions.