〔Abstract〕 Objective To observe the clinical efficacy of Zhuifengtuogu capsule combined with western medicine in the treatment of rheumatic arthritis with cold-dampness obstruction syndrome. Methods 100 patients with rheumatoid arthritis with cold-dampness obstruction syndrome treated in Fengqiu County people's Hospital from March 2018 to February 2019 were randomly divided into observation group (n = 50) and control group (n = 50). The control group was given methotrexate tablets, and the observation group was given Zhuifengtuogu capsule on the basis of the control group. The curative effect, average grip strength of both hands, C-reactive protein, erythrocyte sedimentation rate and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 94.00 %, which was signifi cantly higher than that of the control group (74.00 %) (P < 0.05). There was no signifi cant difference in average grip strength, C-reactive protein and erythrocyte sedimentation rate between the two groups before treatment (P > 0.05). After treatment, the average grip strength, C-reactive protein and erythrocyte sedimentation rate of the two groups were improved in varying degrees, and the average grip strength of the observation group was signifi cantly higher than that of the control group, while the C-reactive protein and erythrocyte sedimentation rate of the observation group were signifi cantly lower than those of the control group (P < 0.05). The difference was statistically signifi cant (P < 0.05). The incidence of adverse reactions in the observation group (16.00 %) was signifi cantly lower than that in the control group (38.00 %) (P < 0.05). Conclusion Zhuifeng Tougu capsule combined with western medicine is effective in the treatment of cold-dampness obstruction syndrome of rheumatoid arthritis and reduces adverse reactions.