〔Abstract〕 Objective To explore the relationship between immune antibodies and decreased ovarian reserve (DOR). Methods A total of 91 DOR patients who attended the gynecological outpatient clinic of Guangdong Family Planning Hospital from May 2016 to December 2019 were selected as the research object and used as the observation group. Another 80 patients with normal ovarian function were selected during the same period of physical examination. The subjects served as the control group, and the serum anti-ovarian antibodies (AoAb), anti-cardiolipin antibodies (AcAb), anti-thyroglobulin antibodies (TG-Ab) and thyroid peroxidase antibodies ( TPoAb) detection value and positive rate. Results There was no signifi cant difference in age, body mass index (BMI), and estradiol (E2) levels between the two groups of study subjects (P > 0.05); the observation group had higher levels of follicle stimulating hormone (FSH) than the control In the group, the level of anti-Müllerian hormone (AMH) was lower than that in the control group, and the differences were statistically signifi cant (P < 0.05); there was no statistical difference in the levels and positive rates of TG-Ab, TPO-Ab and AcAb between the two groups Scientifi c signifi cance (P > 0.05); the AoAb level and positive rate of the observation group were higher than those of the control group, and the difference was statistically signifi cant (P < 0.05). Conclusion DOR patients with normal chromosomal karyotype can detect autoimmune antibody dysfunction, and the detection of AoAb is important for the diagnosis of DOR.