〔Abstract〕 Objective To validate the role of using multiple echocardiographic views in visualizing the geometry of atrial septal defect (ASD) as well as screening candidates for interventional device occlusion for ASDs. Methods Thirty-four patients aged from 4 to 53 years, with secundum ASD, underwent percutaneous interventional device occlusion of defect. Multiple echocardiographic views: 1. parasternal four-chamber view, 2. parasternal great vessel short-axial view and 3. subcostal bi-atrial view were used to measure defect size and to determine important rims supporting structures. Results Single case failed to the procedure by multiple attempts due to large ASD, excluded from this study and 33 patients with ASDs had completed the procedure, with defect sizes of 4 mm to 34 mm in patients with ASD were measured by pre-closured echocardiography and ASD occluders of waist size of 12 mm to 40 mm were deployed during procedure. The scattergram illustrated ASD occluder waist size increased with the increase of ASD defect and showed the trend of linear. Pearson correlation coeffi cient of r = 0.837, P = 0.00. According to α = 0.05 level, can think has a positive linear relationship between ASDs occluder waist size and ASDs size. Neither there was an occluder rocking and dislocation, a residual shunting and a signifi cant atrio-ventricular valve regurgitation determined by post-closured echocardiography, nor onset of severe arrhymia. Conclusion The role of multiple views, especially three views of echocardiography in pre-closure may more intuitively observe the ASD geometry and more definitely visualize the adjacent structures, which may guide the selection of occluders’ type and size during interventional occlusion of ASDs.