Abstract:〔Abstract〕 Objective To explore the effect of thunder-fire moxibustion combined with press needle in the treatment of allergic rhinitis (AR) of lung spleen deficiency syndrome based on the theory of "Four Seas" and its effect on immune function. Methods From May 2022 to August 2023, 100 patients with AR of lung spleen deficiency syndrome in Zhongshan Hospital of Traditional Chinese Medicine were selected as the research objects. They were randomly divided into an observation group (50 cases) and a control group (50 cases). The control group was treated with conventional Western medicine, and the observation group was treated with thunder-fire moxibustion combined with press needle by the traditional "Four Seas" theory. The clinical efficacy of the two groups of patients was compared. Results After treatment, the rhinitis symptom score and the level of immunoglobulin (Ig) E of the observation group were lower than those of the control group, and the differences were statistically significant (P < 0.05). After treatment, the nasal mucosa indication score of the observation group was lower than that of the control group, and the level of cluster of differentiation (CD) 4+ was significantly higher than that of the control group, and the differences were statistically significant (P < 0.05). The recurrence rate of the observation group was significantly lower than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Thunder-fire moxibustion combined with press needle treatment guided by "Four Seas" theory can significantly improve the clinical symptoms of AR patients with lung spleen deficiency syndrome, and the recurrence rate is relatively low.