Abstract:〔Abstract〕 Objective Based on the 3D modeling technology of nasopharynx computed tomography (CT) and magnetic resonance imaging (MRI) image fusion, the three-dimensional virtual model of nasopharynx was made, and its significance in clinical practice teaching mode and clinical work was discussed. Methods Firstly, three patients with nasopharyngeal carcinoma were scanned with MRI to obtain DICOM data, and the tumor and internal blood vessel models were segmented and reconstructed by medical influence technology. Then the CT data are segmented, and the nasopharynx and internal vascular models are reconstructed. Finally, the two models are registered and fused to build a composite three-dimensional virtual model of nasopharynx disease. The model was scored by 15 doctors from the Department of oncology and otolaryngology. Results The three-dimensional virtual model of nasopharynx with high fidelity and equal proportion was made, and a questionnaire survey was conducted on the model, and the score of the questionnaire was more than 4. Conclusion Using the fusion method of CT and MRI images of nasopharynx, the three-dimensional virtual model made by 3D modeling technology has important practical significance for oncologists and otolaryngologists in the aspects of nasopharynx anatomy, disease understanding, application of radiotherapy target delineation, doctor-patient communication and clinical training.